To kick-off PRiME’s new global partnerships program funded by the Connaught Global Challenge Fund, we are launching the Connaught Global Challenge Series which will feature a virtual mini-symposium with each of our four partner institutions.

Opening the series next month is a two-day session with the University of California, San Francisco (UCSF), featuring investigators from both PRiME and UCSF discussing innovative research in proteostasis and high-throughput technologies advancing precision medicine.

Program details are below.

NOTE: This event has already taken place. You can watch this seminar series on PRiME’s YouTube channel.

PRiME - UCSF Mini Symposium

Tuesday December 1 & Wednesday December 2, 2020

Day 1: Chemical & Structural Biology of Proteostasis

1:00 – 1:15 Introduction to PRiME and the Connaught Global Challenge Program

1:15 – 1:35 Michelle Arkin, UCSF
Can we discover function-specific inhibitors of multifunctional enzymes like p97?

1:35 – 1:55 Lewis Kay, UofT
Why electrons and x-rays won’t solve the drug problem

2:00 – 2:20 Jason Gestwicki, UCSF
Targeting protein-protein interactions in the molecular chaperone network

2:20 – 2:40 John Rubinstein, UofT
CryoEM of drug targets in mycobacterial respiration

2:45 – 3:30 Questions & open discussion

Watch Day 1

Day 2: High Throughput Technologies to Accelerate Biology

December 2 Agenda – Michelle Arkin to moderate session

1:00 – 1:15 Introduction to PRiME and the Connaught Global Challenge Program

1:15 – 1:35 Hana El-Samad, UCSF
Biological feedback loops - an old problem and a new frontier

1:35 – 1:55 Jason Moffat, UofT
Genotype-to-phenotype maps: one core gene set at a time

2:00 – 2:20 Zev Gartner, UCSF
Building tissues to understand how tissues build themselves

2:20 – 2:40 Shana Kelley, UofT
Rare cell profiling for high-throughput biology